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Updated: Mar 7, 2026

Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
Published on: January 15, 2018
Facile synthesis of stable, water soluble, dendron-coated gold nanoparticles
Alan E Enciso1, Giovanni Doni2, Riccardo Nifosì3
1Department of Chemistry, Texas Christian University, Fort Worth, TX 76109, USA.
Abstract:
Upon reduction with sodium borohydride, diazonium tetrachloroaurate salts of triazine dendrons yield dendron-coated gold nanoparticles connected by a gold-carbon bond. These robust nanoparticles are stable in water and toluene solutions for longer than one year and present surface groups that can be reacted to change surface chemistry and manipulate solubility. Molecular modeling was used to provide insight on the hydration of the nanoparticles and their observed solubilties.

