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Updated: Mar 7, 2026
Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level
Published on: March 14, 2022
Endothelial cell metabolism: an update anno 2017
Laure-Anne Teuwen1, Nihed Draoui, Charlotte Dubois
1aLaboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven, Belgium bLaboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, Center for Cancer Biology (CCB), VIB, Leuven, Belgium cGZA Hospitals Sint-Augustinus, Wilrijk and Center for Oncological Research, University of Antwerp, Antwerp, Belgium.
Endothelial cell metabolism, particularly glycolysis and fatty acid oxidation, regulates angiogenesis. Targeting key enzymes like PFKFB3 and carnitine palmitoyltransferase 1a offers new therapeutic strategies for angiogenesis-associated diseases.
Area of Science:
- Biochemistry
- Cell Biology
- Oncology
Background:
- Endothelial cell metabolism is crucial for angiogenesis.
- Dysregulated angiogenesis is implicated in diseases like cancer.
- Metabolic pathways offer potential therapeutic targets.
Purpose of the Study:
- Review recent insights into endothelial cell metabolism.
- Discuss its role in physiological and pathological angiogenesis.
- Explore translational implications for disease treatment.
Main Methods:
- Review of current literature on endothelial cell metabolism.
- Analysis of glycolysis and fatty acid oxidation pathways.
- Examination of key regulatory enzymes: PFKFB3 and CPT1a.
Main Results:
- Glycolysis, regulated by PFKFB3, is vital for ATP production, vessel sprouting, and migration.
- PFKFB3 upregulation in tumors leads to dysfunctional vasculature; its blockade normalizes tumor vessels.
- Fatty acid oxidation (FAO), controlled by CPT1a, promotes proliferation and lymphangiogenesis; FAO inhibition reduces pathological angiogenesis.
Conclusions:
- PFKFB3 and CPT1a are key metabolic regulators of angiogenesis.
- These enzymes represent promising therapeutic targets for pathological angiogenesis.
- Targeting endothelial cell metabolism holds potential for treating angiogenesis-associated diseases.
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