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Why is plasma angiotensin-converting enzyme activity elevated in hyperthyroidism?

J E Roulston1, A Gold, M Wright

  • 1University Department of Clinical Chemistry, Royal Infirmary, Edinburgh.

Journal of the Royal Society of Medicine
|August 1, 1987
PubMed
Summary
This summary is machine-generated.

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Thyroid hormones directly increase the synthesis and secretion of angiotensin-converting enzyme (ACE). This study investigated unexplained high ACE levels in hyperthyroidism, ruling out other causes.

Area of Science:

  • Endocrinology
  • Cardiovascular Physiology

Background:

  • Elevated plasma angiotensin-converting enzyme (ACE) is observed in hyperthyroidism but remains mechanistically unexplained.
  • Understanding the source of increased ACE is crucial for managing thyroid-related cardiovascular complications.

Purpose of the Study:

  • To investigate the underlying mechanisms responsible for elevated plasma ACE levels in hyperthyroidism.
  • To differentiate between increased enzyme release and enhanced synthesis as the cause of high ACE.

Main Methods:

  • In vivo studies using thyroid hormone-treated rats to assess enzyme cleavage from lung endothelium.
  • Analysis of ACE levels in patients with specific tissue damage to rule out non-specific release.
  • In vitro cultured cell experiments to evaluate the direct impact of thyroid hormones on ACE production.

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Main Results:

  • Thyroid hormone treatment in rats did not increase ACE cleavage from lung endothelium.
  • Patient data with tissue damage did not support non-specific ACE release.
  • Cultured cells demonstrated that thyroid hormones directly stimulate ACE synthesis and secretion.

Conclusions:

  • Thyroid hormones directly modulate the synthesis and secretion of angiotensin-converting enzyme.
  • The elevated plasma ACE in hyperthyroidism is primarily due to direct hormonal stimulation of ACE production, not increased release from damaged tissues or endothelium.