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Psoriasis and comorbid diseases: Epidemiology.
Junko Takeshita1, Sungat Grewal2, Sinéad M Langan3
1Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; Department of Epidemiology and Biostatistics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Journal of the American Academy of Dermatology
|February 19, 2017
Summary
Psoriasis, a chronic skin condition, is linked to systemic inflammation and various comorbidities like psoriatic arthritis, cardiometabolic, and mood disorders. Understanding these connections is crucial for comprehensive patient care.
Area of Science:
- Dermatology
- Immunology
- Systemic Inflammatory Diseases
Background:
- Psoriasis is a prevalent chronic inflammatory skin condition.
- It is increasingly recognized as a systemic disorder with significant comorbidities.
- Psoriatic arthritis is a well-established comorbidity.
Purpose of the Study:
- To review the expanding literature on psoriasis comorbidities.
- To highlight associations beyond psoriatic arthritis.
- To emphasize the need for comprehensive care and provider education.
Main Methods:
- Literature review of studies on psoriasis and its comorbidities.
- Analysis of reported associations across diverse populations.
- Synthesis of current hypotheses regarding pathogenesis.
Main Results:
- Psoriasis is associated with cardiometabolic, gastrointestinal, kidney diseases, malignancy, infection, and mood disorders.
- Shared inflammatory pathways, genetic factors, and risk factors are implicated.
- The full spectrum of comorbidities continues to expand.
Conclusions:
- Psoriasis is a systemic disease with a wide range of associated conditions.
- Understanding these comorbidities is vital for holistic patient management.
- Educating healthcare providers is essential for optimal patient outcomes.
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