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Psoriasis and comorbid diseases: Implications for management.

Junko Takeshita1, Sungat Grewal2, Sinéad M Langan3

  • 1Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; Department of Epidemiology and Biostatistics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

Journal of the American Academy of Dermatology
|February 19, 2017
PubMed
Summary

Psoriasis patients face increased risks for cardiometabolic diseases and other serious health conditions. Early recognition and management of these comorbidities are crucial for comprehensive patient care.

Keywords:
Crohn's diseasecardiovascular diseasechronic kidney diseasecomorbiditiesdepressioninfectionlymphomametabolic syndromenonalcoholic fatty liver diseasepsoriasispsoriatic arthritisscreeningvaccination

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Area of Science:

  • Dermatology and Internal Medicine
  • Epidemiology of Chronic Diseases

Background:

  • Psoriasis is increasingly recognized as a systemic inflammatory disease.
  • Epidemiologic data suggest psoriasis is linked to cardiometabolic disease.
  • Associations extend to other comorbidities, including kidney, liver, and mood disorders.

Purpose of the Study:

  • To review the clinical implications of comorbidities associated with psoriasis.
  • To provide recommendations for the clinical management of psoriasis comorbidities.

Main Methods:

  • Review of existing epidemiologic and clinical data.
  • Synthesis of evidence on psoriasis comorbidities.
  • Analysis of clinical management strategies.

Main Results:

  • Psoriasis is associated with an elevated risk of cardiometabolic disease.
  • Significant links exist between psoriasis and chronic kidney disease, inflammatory bowel disease, hepatic disease, malignancies, infections, and mood disorders.
  • Comorbidities significantly impact patient care and outcomes.

Conclusions:

  • Comprehensive care for psoriasis necessitates recognizing and managing its associated comorbid conditions.
  • Proactive management of comorbidities can improve overall patient health and prognosis.