Related Experiment Video

Updated: Mar 7, 2026

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
07:00

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

Published on: April 1, 2019

10.5K

Correlation between the GP78 Gene Polymorphism and Coronary Atherosclerotic Heart Disease

Long Wang1, Hua-Cheng Li2, Jian Zhou3

  • 1Department of Geriatrics, The First Hospital of Lanzhou University, China.

Hellenic Journal of Cardiology : HJC = Hellenike Kardiologike Epitheorese
|February 19, 2017
PubMed

Insights

Genetic variations in the GP78 gene are linked to coronary atherosclerotic heart disease, impacting blood fat, blood glucose, and blood pressure levels. This study highlights a significant correlation at the 145 locus.

Area of Science:

  • Genetics and Molecular Biology
  • Cardiovascular Disease Research
  • Metabolic Syndrome Studies

Background:

  • Coronary atherosclerotic heart disease (CAD) is a significant global health concern.
  • Genetic factors play a crucial role in the development of CAD and associated metabolic abnormalities.
  • The GP78 gene's role in CAD pathogenesis requires further elucidation.

Purpose of the Study:

  • To investigate the association between GP78 gene polymorphism and coronary atherosclerotic heart disease.
  • To examine the correlation between GP78 gene variations and key metabolic indicators including blood fat, blood glucose, and blood pressure.
  • To determine the clinical significance of GP78 gene polymorphism in cardiovascular health.

Main Methods:

  • Case-control study comparing 72 CAD patients with 68 healthy controls.
  • Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) used to analyze GP78 gene polymorphism.
  • Quantitative PCR, ELISA, and Western blotting assessed GP78 gene expression levels.
  • Blood fat, blood glucose, and blood pressure measurements were conducted for all participants.

Main Results:

  • Significant differences in GP78 gene polymorphism (Arg/Arg, Arg/Gly, Gly/Gly) at the 145 locus were observed between CAD patients and controls (P<0.05).
  • Elevated percentages of specific GP78 genotypes were found in the coronary atherosclerotic heart disease group compared to the healthy control group.
  • Statistically significant differences in blood fat, blood glucose, and blood pressure levels were detected between the two groups (P<0.05).

Conclusions:

  • The 145 locus of the GP78 gene is significantly correlated with coronary atherosclerotic heart disease.
  • GP78 gene polymorphism is associated with alterations in blood fat, blood glucose, and blood pressure.
  • These findings suggest GP78 gene variations may serve as a potential biomarker for CAD risk assessment.
Abstract

Keywords:
blood fatblood glucoseblood pressurecoronary sclerosisheart disease

More Related Videos

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.9K
High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

12.3K

Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
19.2K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
16.2K
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters01:16

Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters

The pharmacogenetics of drug transporters is increasingly recognized as a critical factor influencing interindividual variability in drug absorption, distribution, and elimination. These membrane-bound proteins regulate drugs' movement across cellular barriers by actively pumping them out (efflux) or facilitating their uptake (influx). Among the major transporter families, ATP-binding cassette (ABC) and solute carrier (SLC) transporters play particularly prominent roles. Genetic polymorphisms...
85
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
56
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.4K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
851