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Related Experiment Video

Updated: Mar 7, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

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Published on: June 8, 2022

Organ-specific biomarkers in lupus.

Haijing Wu¹, Jinrong Zeng¹, Jinghua Yin¹

¹Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, China.

Autoimmunity Reviews

|February 19, 2017

Summary

Biomarkers are crucial for diagnosing and managing systemic lupus erythematosus (SLE), a complex autoimmune disease. This review highlights novel biomarkers for personalized treatment strategies and predicting disease progression.

Keywords:

Cytokines Epigenetics Genetics Systemic lupus erythematosus Tissue-specific biomarkers

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Area of Science:

Immunology
Genetics
Biochemistry

Background:

Systemic lupus erythematosus (SLE) is a complex autoimmune disease affecting multiple organs.
Its exact cause is unknown, but genetic and epigenetic factors are implicated.
Current clinical tests struggle to accurately assess organ involvement and disease activity.

Purpose of the Study:

To review conventional and novel biomarkers for SLE.
To discuss their role in tissue-specific diagnosis, prognosis, and disease activity assessment.
To provide insights for individualized SLE therapy.

Main Methods:

Review of existing literature on SLE biomarkers.
Analysis of genomic, transcriptomic, and proteomic data.
Tissue-specific assessment of biomarker roles.

Main Results:

Numerous promising biomarkers identified across different molecular levels.
Biomarkers show potential for diagnosing organ involvement and predicting manifestations.
Correlation between biomarkers and histological findings is discussed.

Conclusions:

Biomarkers are essential for objective assessment and personalized treatment of SLE.
Tissue-specific biomarkers can guide individualized therapeutic decisions.
Further research into novel biomarkers will enhance SLE management.