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Biphasic responses, quantal signals and cellular behaviour.

A D Robertson1, J F Grutsch

  • 1Research, Testing and Development Corporation, Lexington, Georgia 30648.

Journal of Theoretical Biology
|March 7, 1987
PubMed
Summary
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Biological systems commonly exhibit biphasic responses to chemical signals, with thresholds and upper limits. This non-linear signaling drives cellular differentiation and developmental complexity across diverse organisms.

Area of Science:

  • Cellular Biology
  • Developmental Biology
  • Systems Biology

Background:

  • Biological systems frequently display thresholds, but biphasic responses (thresholds and upper limits) are also common.
  • These biphasic responses are prevalent in systems where chemical signals regulate cellular behavior.
  • Such signaling can lead to tissue partitioning and distinct developmental/evolutionary trajectories within an organism.

Purpose of the Study:

  • To investigate the prevalence and implications of biphasic responses in biological systems.
  • To demonstrate how non-linear concentration-dependent chemical signaling shapes cellular behavior and development.
  • To explain the complexity of biological development through the lens of these signaling mechanisms.

Main Methods:

  • Analysis of existing biological system models exhibiting thresholds and upper limits.

Related Experiment Videos

  • Examination of cellular behavior in response to varying chemical signal concentrations.
  • Comparative study across different biological systems, including mammalian immune cells and slime mold.

    • Main Results:

    • Biphasic responses are widespread, particularly in chemical signal-controlled cellular behaviors.
    • Common features include all-or-nothing responses and distinct cell type behaviors across different concentration ranges of the same signal.
    • Examples include mammalian immune cell differentiation and slime mold development.

    Conclusions:

    • The interaction between simple cellular behaviors and non-linear chemical signals explains developmental complexity.
    • Biphasic signaling provides a fundamental principle underlying diverse biological processes.
    • Understanding these non-linear dynamics is crucial for comprehending development and evolution.