Association between cognitive impairment and urinary dysfunction in Parkinson's disease
Zuzanna Tkaczynska1,2, Andrea Pilotto2,3, Sara Becker1,2
1German Center of Neurodegenerative Diseases (DZNE), Bonn, Germany.
Journal of Neural Transmission (Vienna, Austria : 1996)
|February 19, 2017
Summary
Urinary dysfunction (UD) in Parkinson's disease (PD) is linked to cognitive deficits, particularly in global cognition and visuo-constructive functions. This association appears independent of symptomatic treatments, highlighting a significant non-motor feature in PD progression.
Area of Science:
- Neurology
- Urology
- Neuroscience
Background:
- Urinary dysfunction (UD) is a prevalent non-motor symptom in Parkinson's disease (PD).
- The relationship between UD and cognitive impairment in PD, especially concerning frontal cortex involvement, remains incompletely understood.
- Neurodegeneration in cortical and subcortical areas may underlie both UD and cognitive deficits in PD.
Purpose of the Study:
- To investigate the association between urinary dysfunction and cognitive deficits in Parkinson's disease patients.
- To examine the impact of UD on various cognitive domains and daily living activities.
- To explore whether this association is influenced by symptomatic treatments.
Main Methods:
- A cohort of 94 Parkinson's disease patients was assessed.
- Comprehensive evaluations included motor, cognitive, and non-motor assessments.
- Patients were categorized based on the presence and medication use for urinary dysfunction.
Main Results:
- Over half of PD patients (55.3%) reported UD, with 17% requiring urological treatment.
- Patients with UD demonstrated poorer performance in global cognition, visuo-constructive functions, and instrumental activities of daily living compared to those without UD.
- PD patients with UD medication showed worse global cognition and visuo-constructive functions than those without UD medication, irrespective of anticholinergic effects.
Conclusions:
- Cognitive impairment is associated with urinary dysfunction in Parkinson's disease.
- This association persists independently of symptomatic treatments for UD.
- Urinary dysfunction represents a significant indicator of cognitive decline in PD patients.
Related Concept Videos
01:15Parkinson's Disease: Overview
2.3K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.3K
01:24Parkinson's Disease: Treatment
1.3K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.3K
01:20Disorders of the Urinary System
1.4K
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
1.4K
01:37Neural Regulation
43.9K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.9K
01:21Nursing Assessment of the Genitourinary System I: Health History
524
The genitourinary system is critical to maintaining fluid balance, waste elimination, and reproductive function. Nurses play a vital role in assessing this system, beginning with a thorough health history. This process involves gathering patient information, identifying risk factors, and recognizing symptoms of genitourinary disorders. Early detection is vital for timely interventions and management.1. Gathering Patient InformationA complete health history includes the patient’s personal,...
524
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
511
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
511