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Updated: Mar 7, 2026

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
Published on: March 30, 2019
MicroRNA-155 targets MAP3K10 and regulates osteosarcoma cell growth
Chuangjian Wang1, Xiaobo Zhang2, Chunlin Zhang1
1Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, No. 1 JianShe Road, Zhengzhou, Henan 450000, China.
Abstract:
Osteosarcoma is the most common type of bone cancer prevalent in young adults. Recent studies suggested that aberrant microRNA expression plays an essential role in osteosarcoma pathogenesis. In this study, we found miR-155 up-regulation in different osteosarcoma cell lines U2OS, Saos-2 and MG-63. Through bioinformatic prediction and analysis, we identified its target MAP3K10 that involved in cell proliferation and apoptosis. This work demonstrates novel interaction between microRNA, intercellular MAPK signaling and apoptosis in osteosarcoma, which will provide targets for therapeutic development.
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