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Related Experiment Video

Updated: Mar 7, 2026

Protocol to Create Chronic Wounds in Diabetic Mice
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Vasculitic and autoimmune wounds.

Victoria K Shanmugam1, Divya Angra2, Hamza Rahimi2

  • 1Division of Rheumatology, The George Washington University, School of Medicine and Health Sciences, Washington, D.C..

Journal of Vascular Surgery. Venous and Lymphatic Disorders
|February 20, 2017
PubMed
Summary

Autoimmune and vasculitic conditions cause 20-23% of nonhealing chronic wounds. Early consideration of these systemic diseases and a multidisciplinary approach improve outcomes for refractory chronic wounds.

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Area of Science:

  • Vascular Surgery
  • Rheumatology
  • Dermatology

Background:

  • Chronic wounds significantly impact morbidity and mortality.
  • 20-23% of nonhealing wounds refractory to vascular intervention stem from autoimmune diseases like vasculitis.
  • These conditions present unique challenges in wound management.

Purpose of the Study:

  • To review literature on refractory chronic wounds linked to vasculitis and autoimmune diseases.
  • To analyze clinical outcomes of these wounds with various interventions.
  • To provide insights into managing complex chronic wounds.

Main Methods:

  • Comprehensive electronic search of MEDLINE, PubMed, Cochrane Library, and Scopus.
  • Inclusion of full-text articles in English up to March 1, 2016, focusing on autoimmune-associated chronic wounds.
  • Qualitative analysis due to data heterogeneity, assessing outcomes like amputation, healing, and survival.

Main Results:

  • Vasculitis and autoimmune diseases are implicated in 20-23% of chronic lower extremity ulcers.
  • Patients with autoimmune disease experience significantly higher split-thickness skin graft failure rates (50% vs. 97%).
  • Discussion of management strategies for leg ulcers in this patient population.

Conclusions:

  • Consider autoimmune and vasculitic causes in chronic wounds unresponsive to standard care.
  • A multidisciplinary approach involving rheumatologists is crucial for diagnosis and improved outcomes.
  • Early identification and integrated management enhance clinical results for challenging wounds.