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Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers
Published on: July 15, 2019
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Stress and Salivary Glands
Beata Keremi1, Anita Beck1, Tibor Karoly Fabian2
1Department of Oral Biology, Semmelweis University, Budapest. Hungary.
Current Pharmaceutical Design
|February 21, 2017
Summary
Saliva composition changes dramatically under stress due to sympathetic nervous system activation. These salivary stress biosensors offer a non-invasive method for monitoring stress levels.
Area of Science:
- Physiology
- Neuroendocrinology
- Biochemistry
Background:
- Salivary glands secrete fluid and proteins, regulated by the autonomic nervous system.
- Parasympathetic activity controls fluid/electrolyte secretion; sympathetic stimulation triggers protein release.
- Stress activates the hypothalamic-pituitary-adrenal axis, impacting the sympathetic nervous system.
Purpose of the Study:
- To overview recognized salivary stress biosensors.
- To demonstrate saliva's diagnostic potential for stress-related conditions.
- To explore future applications of salivary biomarkers for stress assessment.
Main Methods:
- Review of existing literature on salivary components and stress.
- Analysis of the relationship between sympathetic activity and salivary composition.
- Identification of potential salivary stress biomarkers.
Main Results:
- Stress induces significant alterations in saliva composition, particularly protein content.
- Salivary protein secretion is highly sensitive to sympathetic nervous system control.
- Compounds like amylase, cortisol, and heat shock proteins are identified as potential stress indicators.
Conclusions:
- Saliva composition changes serve as sensitive indicators of stress.
- Saliva is a valuable, non-invasive tool for diagnosing stress and systemic disorders.
- Standardization of salivary biomarkers will enable routine clinical use for stress level estimation.
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