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Oxidative Stress and Cardiovascular Aging: Interaction Between NRF-2 and ADMA
Nandini Nair1, Enrique Gongora2
1Division of Cardiology, Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, United States.
Current Cardiology Reviews
|February 21, 2017
Summary
Antioxidant therapies targeting the nrf-2 pathway can improve endothelial function by reducing ADMA levels and increasing nitric oxide (NO) production, benefiting cardiovascular health.
Area of Science:
- Cardiovascular Science
- Molecular Biology
- Pharmacology
Background:
- Oxidative stress contributes to cardiovascular aging and endothelial dysfunction.
- The review explores the interplay between nrf-2 and ADMA in the nitric oxide pathway.
Purpose of the Study:
- To review the literature on nrf-2 and ADMA's influence on nitric oxide (NO) production and cardiovascular function.
- To investigate how nrf-2 activation impacts ADMA levels and endothelial homeostasis.
Main Methods:
- Systematic literature review from 1990 to 2016.
- Searches conducted on PubMed and Google Scholar.
Main Results:
- nrf-2 activation upregulates DDAH I, which degrades ADMA.
- Reduced ADMA levels enhance nitric oxide (NO) production, supporting endothelial function.
- This pathway influences cardiovascular homeostasis.
Conclusions:
- nrf-2 and DDAH I modulation offer potential therapeutic targets for cardiovascular diseases.
- Further research, including human randomized controlled trials, is needed to validate these findings.
- Therapeutic strategies could focus on downstream molecules like DDAH I to regulate ADMA levels.
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