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Effect of cellular and extracellular pathology assessed by T1 mapping on regional contractile function in

Peter P Swoboda1, Adam K McDiarmid2, Bara Erhayiem2

  • 1Multidisciplinary Cardiovascular Research Centre (MCRC) & Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Clarendon Way, Leeds, LS2 9JT, UK. p.swoboda@leeds.ac.uk.

Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance
|February 21, 2017
PubMed

Insights

In hypertrophic cardiomyopathy (HCM), regional contractile dysfunction is linked to myocardial thickness and native T1 values, not fibrosis markers like ECV or LGE. These findings point to cellular changes, not just extracellular expansion, affecting contractility.

Area of Science:

  • Cardiology
  • Biomedical Imaging
  • Biophysics

Background:

  • Regional contractile dysfunction is a common issue in hypertrophic cardiomyopathy (HCM).
  • Understanding the link between tissue characteristics and this dysfunction is crucial for patient management.

Purpose of the Study:

  • To investigate how different tissue characteristics in HCM contribute to regional contractile dysfunction.
  • To determine the relationship between myocardial hypertrophy, tissue composition, and regional strain in HCM patients.

Main Methods:

  • Prospective study of 50 HCM patients using 3.0 Tesla cardiovascular magnetic resonance (CMR).
  • Assessed segment thickness, native T1, extracellular volume (ECV), late gadolinium enhancement (LGE), and regional strain.
  • Utilized mixed effects modeling to analyze associations between function, hypertrophy, and tissue characteristics.

Main Results:

  • Segment thickness, native T1, ECV, and LGE were all associated with regional strain.
  • Multivariable analysis showed strain associated with segment thickness and native T1, but not ECV or LGE.
  • Late gadolinium enhancement (LGE) showed a significant association with circumferential strain measured by tissue tagging.

Conclusions:

  • Impaired contractility in HCM is primarily associated with the degree of hypertrophy and native T1 values.
  • Markers of extracellular fibrosis (ECV, LGE) were not significantly associated with impaired contractility.
  • Findings suggest cellular changes, rather than extracellular expansion, mediate contractility impairment in HCM.
Abstract

Keywords:
Extracellular volumeFeature trackingHypertrophic cardiomyopathyStrainT1 mappingTissue tagging

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