Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

10.2K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
10.2K
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

672
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
672
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K
Tumor Immunotherapy01:27

Tumor Immunotherapy

2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

7.7K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
7.7K
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

875
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
875

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Remedy for Intussusception of the Bowels.

The North-Western medical and surgical journal·2023
Same author

Canonical and non-canonical NF-κB signaling promotes breast cancer tumor-initiating cells.

Oncogene·2013
Same author

NF-κB suppresses ROS levels in BCR-ABL(+) cells to prevent activation of JNK and cell death.

Oncogene·2011
Same author

IKK-dependent, NF-κB-independent control of autophagic gene expression.

Oncogene·2010
Same author

Her2 activates NF-kappaB and induces invasion through the canonical pathway involving IKKalpha.

Oncogene·2009
Same author

Ex vivo inhibition of NF-kappaB signaling in alloreactive T-cells prevents graft-versus-host disease.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2009
Same journal

Transcriptomic insights into epigenetic and immunomodulatory roles of nuclear histone genes in bladder cancer: A bioinformatics approach.

Advances in protein chemistry and structural biology·2026
Same journal

Investigating the immune-modulatory association of miRNAs in HPV-associated HNSCC individuals: A bioinformatics approach.

Advances in protein chemistry and structural biology·2026
Same journal

VISTA as a Double-Edged immune checkpoint molecule in cancer and autoimmunity.

Advances in protein chemistry and structural biology·2026
Same journal

Aptamers as immunomodulatory therapeutic alternatives targeting neglected tropical diseases (NTDs).

Advances in protein chemistry and structural biology·2026
Same journal

Peptides and peptidomimetics as immunomodulator agents targeting neglected tropical diseases.

Advances in protein chemistry and structural biology·2026
Same journal

Transcriptomic profiling reveals immune pathway dysregulation and key interferon-responsive genes in Systemic Lupus Erythematosus.

Advances in protein chemistry and structural biology·2026
See all related articles

Related Experiment Video

Updated: Mar 7, 2026

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
11:27

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α

Published on: November 2, 2018

9.6K

Targeting IKK and NF-κB for Therapy.

J K Durand1, A S Baldwin2

  • 1Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC, United States; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States.

Advances in Protein Chemistry and Structural Biology
|February 21, 2017
PubMed
Summary
This summary is machine-generated.

The NF-κB pathway regulates immune responses, cell proliferation, and survival. Inhibiting this pathway, including its kinase IKK, offers therapeutic strategies for cancer and chronic inflammation.

Keywords:
CancerIKKInflammationNF-κBTherapeutic targetsTranscription factor

More Related Videos

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions
08:17

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions

Published on: October 30, 2016

22.1K
Production, Crystallization, and Structure Determination of the IKK-binding Domain of NEMO
13:02

Production, Crystallization, and Structure Determination of the IKK-binding Domain of NEMO

Published on: December 28, 2019

8.0K

Related Experiment Videos

Last Updated: Mar 7, 2026

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
11:27

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α

Published on: November 2, 2018

9.6K
Flow Cytometry-based Assay for the Monitoring of NK Cell Functions
08:17

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions

Published on: October 30, 2016

22.1K
Production, Crystallization, and Structure Determination of the IKK-binding Domain of NEMO
13:02

Production, Crystallization, and Structure Determination of the IKK-binding Domain of NEMO

Published on: December 28, 2019

8.0K

Area of Science:

  • Molecular Biology
  • Immunology
  • Cell Biology

Background:

  • The Nuclear Factor kappa B (NF-κB) family of transcription factors plays a crucial role in immune responses, cellular proliferation, and survival.
  • Dysregulation of NF-κB signaling is implicated in the pathogenesis of various diseases, notably chronic inflammation and cancer.

Purpose of the Study:

  • To review the conditions that trigger NF-κB pathway activation.
  • To examine the consequences of constitutive NF-κB activation.
  • To outline current strategies for inhibiting NF-κB signaling.

Main Methods:

  • Literature review of NF-κB pathway activation.
  • Analysis of the effects of constitutive NF-κB activation.
  • Survey of therapeutic inhibition strategies for NF-κB and its activating kinase, IKK.

Main Results:

  • NF-κB activation is influenced by various cellular conditions.
  • Constitutive activation of NF-κB promotes disease progression.
  • Targeting NF-κB and IKK presents viable therapeutic avenues.

Conclusions:

  • Understanding NF-κB pathway dynamics is critical for disease intervention.
  • Inhibition of NF-κB signaling holds promise for treating inflammatory diseases and cancer.