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Related Concept Videos

Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
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Antigen Processing Pathways01:31

Antigen Processing Pathways

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MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

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The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
10.0K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

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The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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Related Experiment Video

Updated: Mar 7, 2026

Assessing the Expression of Major Histocompatibility Complex Class I on Primary Murine Hippocampal Neurons by Flow Cytometry
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Assessing the Expression of Major Histocompatibility Complex Class I on Primary Murine Hippocampal Neurons by Flow Cytometry

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Emerging Major Histocompatibility Complex Class I-Related Functions of NLRC5.

S T Chelbi1, A T Dang1, G Guarda1

  • 1University of Lausanne, Lausanne, Switzerland.

Advances in Immunology
|February 21, 2017
PubMed
Summary

NLRC5, a key regulator of major histocompatibility complex (MHC) class I genes, is crucial for CD8+ T and NK cell functions in immunity and disease. Understanding NLRC5 mechanisms is vital for its therapeutic potential.

Keywords:
CD8(+) T cellsCIITAMHC class INK cellsNLRNLRC5

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Examining the Role of Nasopharyngeal-associated Lymphoreticular Tissue NALT in Mouse Responses to Vaccines
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Examining the Role of Nasopharyngeal-associated Lymphoreticular Tissue NALT in Mouse Responses to Vaccines

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Related Experiment Videos

Last Updated: Mar 7, 2026

Assessing the Expression of Major Histocompatibility Complex Class I on Primary Murine Hippocampal Neurons by Flow Cytometry
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Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
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Examining the Role of Nasopharyngeal-associated Lymphoreticular Tissue NALT in Mouse Responses to Vaccines
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Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • NLRC5 (NLR family, CARD domain containing protein 5) regulates major histocompatibility complex (MHC) class I genes.
  • Its function is analogous to CIITA, the master regulator of MHC class II transcription.
  • MHC class I molecules are critical for cytotoxic responses mediated by CD8+ T cells and NK lymphocytes.

Purpose of the Study:

  • To summarize novel insights into NLRC5 molecular mechanisms.
  • To discuss the relevance of NLRC5 in pathological conditions.
  • To evaluate the clinical significance and therapeutic potential of NLRC5.

Main Methods:

  • Review of recent evidence on NLRC5 function.
  • Analysis of emerging data on NLRC5 target genes.
  • Discussion of molecular mechanisms and clinical relevance.

Main Results:

  • NLRC5 plays a key role in transcriptional regulation of MHC class I and related genes.
  • NLRC5 is relevant to the homeostasis and activity of CD8+ T and NK cells.
  • Emerging data highlight NLRC5's central role in infection and cancer.

Conclusions:

  • NLRC5 is a critical regulator of immune responses involving MHC class I.
  • Understanding NLRC5's molecular mechanisms is essential for its therapeutic application.
  • NLRC5 holds significant potential for treating diseases like cancer and infections.