Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Depression01:03

Long-term Depression

3.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.5K
Long-term Depression01:05

Long-term Depression

33.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.6K
Long-term Potentiation01:35

Long-term Potentiation

59.1K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
59.1K
Long-term Potentiation01:25

Long-term Potentiation

3.7K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
3.7K
Neuroplasticity01:01

Neuroplasticity

2.1K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

41 Antifreeze proteins as cryoprotectants in reproductive biology: a systematic review.

Reproduction, fertility, and development·2022
Same author

Xiphinema rivesi from Chile Transmits Tomato ringspot virus to Cucumber.

Plant disease·2019
Same author

Language improvement one week after thrombolysis in acute stroke.

Acta neurologica Scandinavica·2016
Same author

Adaptive preconditioning in neurological diseases - therapeutic insights from proteostatic perturbations.

Brain research·2016
Same author

Cerebral Hemodynamics Patterns by Transcranial Doppler in Patients With Acute Liver Failure.

Transplantation proceedings·2015
Same author

Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.

Cell death & disease·2015
Same journal

Bilateral macronodular and micronodular hyperplasia: Biochemical, radiological and genetic diagnosis.

Vitamins and hormones·2026
Same journal

ACTH independent Cushing's syndrome: Diagnosis and etiology.

Vitamins and hormones·2026
Same journal

Biochemical diagnosis of hypercortisolism: When and how?

Vitamins and hormones·2026
Same journal

New tools for the diagnosis of hypercortisolism.

Vitamins and hormones·2026
Same journal

Cardiometabolic comorbidities in overt Cushing's syndrome.

Vitamins and hormones·2026
Same journal

Molecular profile of Cushing's syndrome.

Vitamins and hormones·2026
See all related articles

Related Experiment Video

Updated: Mar 7, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

13.5K

BDNF and Hippocampal Synaptic Plasticity.

G Leal1, C R Bramham2, C B Duarte3

  • 1CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.

Vitamins and Hormones
|February 21, 2017
PubMed
Summary
This summary is machine-generated.

Brain-derived neurotrophic factor (BDNF) plays a key role in synaptic plasticity, particularly long-term potentiation (LTP) in the hippocampus. This review explores BDNF

Keywords:
BDNFHippocampusLTPSynaptic plasticityTrkB

More Related Videos

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
11:29

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

14.8K
Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System
09:51

Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System

Published on: January 1, 2018

12.2K

Related Experiment Videos

Last Updated: Mar 7, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

13.5K
Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
11:29

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

14.8K
Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System
09:51

Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System

Published on: January 1, 2018

12.2K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Synaptic Plasticity

Background:

  • Brain-derived neurotrophic factor (BDNF) is a neurotrophin highly expressed in the brain, influencing synaptic function.
  • Synaptic activity regulates BDNF transcription, processing, and secretion, suggesting a role in activity-dependent plasticity.
  • Long-term potentiation (LTP) is a key cellular mechanism for learning and memory, involving sustained enhancement of synaptic efficacy.

Purpose of the Study:

  • To review the evidence for BDNF's fundamental role in hippocampal long-term potentiation (LTP).
  • To address key questions regarding BDNF release, action sites, and signaling mechanisms during LTP.
  • To discuss the opposing functions of mature BDNF and its precursor (proBDNF) via TrkB and p75NTR receptors.

Main Methods:

  • Review of existing scientific literature and evidence.
  • Analysis of molecular and signaling pathways involved in BDNF function.
  • Discussion of receptor activation (TrkB, p75NTR) and downstream effects.

Main Results:

  • BDNF is crucial for activity-dependent synaptic plasticity, particularly LTP in the hippocampus.
  • BDNF exerts diverse effects at excitatory synapses through TrkB receptor activation.
  • The immature form, proBDNF, acting via p75NTR, has distinct and often opposing functions, potentially influencing long-term depression.

Conclusions:

  • BDNF is a critical regulator of synaptic plasticity, learning, and memory.
  • Understanding BDNF signaling pathways is essential for elucidating mechanisms of synaptic modification.
  • Synergy between TrkB and glucocorticoid receptor signaling influences cellular responses to stress.