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Microbiological effect of mupirocin and chlorhexidine for Staphylococcus aureus decolonization in community and
Mary-Claire Roghmann1, Alison D Lydecker2, Patricia Langenberg2
1Geriatrics Research Education and Clinical Center, VA Maryland Health Care System, Baltimore, MD, 21201; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, 21201.
Objective:
To compare the presence of Staphylococcus aureus and pathogenic Gram-negative rods (GNR) in the anterior nares, posterior pharynx and three skin sites in community-based adults and nursing home-based adults before and after treatment with nasal mupirocin and topical chlorhexidine.
Methods:
S. aureus-colonized adults were recruited from the community (n=26) and from nursing homes (n=8). Eligible participants were cultured for S. aureus and GNR during two study visits and then received intranasal mupirocin and topical chlorhexidine for 5days, with a 2-month follow-up period.
Results:
After decolonization, we found sustained decreases of S. aureus colonization in nose, throat and skin sites over 4-8weeks in both populations. Intranasal mupirocin did not increase GNR colonization in nose or throat. Chlorhexidine did not decrease GNR colonization in skin sites.
Conclusions:
Decolonization with mupirocin and chlorhexidine leads to a sustained effect on S. aureus colonization without affecting GNR colonization.
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