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Updated: Aug 13, 2026
09:39
Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications
Published on: January 27, 2014
Adenylate cyclase in senescence: catecholamine and parathyroid hormone pathways
1Geriatric Research, Education, and Clinical Center, Veterans Administration Medical Center, Sepulveda, California 91343.
Reviews in Clinical & Basic Pharmacology
|April 1, 1987
Summary
Aging causes complex changes in adenylate cyclase, affecting multiple tissue components. These age-related defects may explain reduced tissue responsiveness to hormones and drugs.
Area of Science:
- Biochemistry
- Gerontology
- Molecular Biology
Background:
- Adenylate cyclase is crucial for cellular signaling.
- Age-related changes in adenylate cyclase activity are observed in various tissues.
- These changes are not attributed to a single cause but can be multifaceted.
Purpose of the Study:
- To investigate the age-related alterations in the adenylate cyclase complex.
- To understand the impact of these changes on cellular function and tissue responsiveness.
Main Methods:
- Analysis of receptor, N-protein, and catalytic components of adenylate cyclase.
- Assessment of age-related changes in enzyme activity and cellular signaling pathways.
Main Results:
- Significant age-related changes occur in the adenylate cyclase complex across different tissues.
- Defects are tissue-specific and potentially multiple, involving receptor, N-protein, and catalytic units.
- Altered receptor levels may correlate with increased circulating agonist levels in aging.
Conclusions:
- Age-related changes in adenylate cyclase are complex and tissue-specific.
- These alterations may contribute to decreased target tissue responsiveness to hormones and drugs.
- Further research is needed to elucidate mechanisms and downstream effects on cAMP-dependent protein kinase activity and protein phosphorylation.
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