Related Experiment Video
Updated: Aug 13, 2026

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications
Published on: January 27, 2014
Adenylate cyclase in senescence: catecholamine and parathyroid hormone pathways
1Geriatric Research, Education, and Clinical Center, Veterans Administration Medical Center, Sepulveda, California 91343.
Abstract:
There are significant changes in the adenylate cyclase complex of many tissues with age. These changes are not due to a single defect in the system. Rather, the defects may vary from tissue to tissue and may be multiple in nature. There are age-related changes described in the receptor, N-protein, and catalytic components of the adenylate cyclase receptor. Alteration of the level of the receptor may reflect increases in the circulating levels of the agonist with age. The mechanisms responsible for alterations in the N-protein and catalytic unit activity remain to be elucidated. Further work is also needed to determine if the age-related changes in cAMP production result in age-related changes in cAMP-dependent protein kinase activity and the phosphorylation of specific proteins. However, the age-related changes in adenylate cyclase activity that have already been described may at least partially explain the decreased responsiveness of some target tissues to hormones and drugs.
More Related Videos
Related Concept Videos
Intracellular Signaling Cascades
GPCRs Regulate Adenylyl Cylase Activity
Two...
cAMP-dependent Protein Kinase Pathways
Calmodulin-dependent Signaling
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
Secondary Messengers in Hormone Action
Many hormones bind to transmembrane G protein-coupled receptors that connect to regulatory G proteins. These G proteins can then activate enzymes such as adenylyl cyclase or phospholipase C. Adenylyl cyclase converts ATP to cAMP, activating...

