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Updated: Mar 7, 2026

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Klotho regulates CA1 hippocampal synaptic plasticity.

Qin Li1, Hai T Vo1, Jing Wang1

  • 1Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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|February 21, 2017
PubMed
Summary
This summary is machine-generated.

Klotho protein impacts cognitive function and lifespan. Loss of klotho impairs cognition and initially enhances hippocampal synaptic plasticity, which is later lost.

Keywords:
brain aginglong-term potentiationpaired-pulse facilitationsynaptic plasticity

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Aging Research

Background:

  • Global klotho overexpression extends lifespan, while klotho deficiency shortens it and impairs cognitive function.
  • Klotho protein's role in cognitive function is linked to its effects on synaptic transmission and plasticity.
  • Previous studies indicate klotho influences cognitive performance, but its precise synaptic mechanisms remain unclear.

Purpose of the Study:

  • To investigate the presence and function of klotho protein at synapses.
  • To determine the effects of klotho manipulation on hippocampal synaptic plasticity.
  • To elucidate the relationship between klotho, synaptic function, and cognitive performance.

Main Methods:

  • Hippocampal fractionation to detect klotho expression in pre- and post-synaptic compartments.
  • Assessment of CA1 hippocampal synaptic plasticity in klotho-deficient and overexpressing mice at various ages.
  • Cognitive function assessment in relation to synaptic plasticity changes.

Main Results:

  • Klotho expression was detected in both pre- and post-synaptic hippocampal compartments.
  • Loss of klotho initially enhanced hippocampal synaptic plasticity in young mice (5 weeks), but this effect was lost by 7 weeks.
  • Klotho overexpressing mice showed no early synaptic plasticity changes, but exhibited decreased long-term potentiation at 6 months.

Conclusions:

  • Klotho protein is localized to hippocampal synapses.
  • Klotho regulates hippocampal synaptic plasticity, which is a key mechanism underlying its effects on cognition.
  • Dysregulation of klotho impacts cognitive function through alterations in synaptic plasticity over time.