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Autoimmune neuropathies associated to rheumatic diseases
Alberto R M Martinez1, Ingrid Faber1, Anamarli Nucci1
1Department of Neurology-Faculty of Medical Science-State University of Campinas, Brazil.
Autoimmunity Reviews
|February 21, 2017
Summary
Autoimmune rheumatic diseases frequently cause peripheral nervous system damage, leading to severe symptoms. Early diagnosis of these immune-mediated neuropathies is crucial for effective treatment and preventing long-term disability.
Area of Science:
- Neurology
- Rheumatology
- Immunology
Background:
- Autoimmune rheumatic diseases often present with systemic manifestations.
- Peripheral nervous system damage is a common, yet under-recognized, complication.
Purpose of the Study:
- To review immune-mediated neuropathies associated with rheumatic diseases.
- To emphasize clinical features and therapeutic strategies for prompt recognition and management.
Main Methods:
- Literature review focusing on immune-mediated neuropathies in rheumatic diseases.
- Analysis of clinical presentations, diagnostic approaches, and treatment options.
Main Results:
- Peripheral nervous system involvement can affect neuron cell bodies, axons, and myelin.
- Neuropathies manifest with sensory, motor, and autonomic symptoms, forming distinct clinical syndromes.
- Key neuropathies include sensory neuronopathies, multiple mononeuropathies, and chronic inflammatory demyelinating polyradiculoneuropathy.
Conclusions:
- Prompt identification of neuropathies in rheumatic diseases is essential for optimal patient outcomes.
- Understanding these neurological complications aids in reducing long-term disability.
- Targeted treatment strategies are vital for managing immune-mediated neuropathies.
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