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Updated: Mar 7, 2026

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
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Published on: July 8, 2012

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Regulation of Inflammation- and Infection-Driven Hematopoiesis

Steffen Boettcher1, Markus G Manz1

  • 1Hematology, University and University Hospital Zurich, Zurich, Switzerland.

Trends in Immunology
|February 21, 2017
PubMed

Insights

During bacterial infections, the body rapidly produces more myeloid immune cells, like neutrophils, through a process called emergency hematopoiesis to fight pathogens.

Area of Science:

  • Immunology
  • Hematopoiesis
  • Microbiology

Background:

  • Innate myeloid immune cells, particularly neutrophils, are crucial for defending against bacterial and fungal infections.
  • Myeloid cells have short lifespans and require constant regeneration from hematopoietic stem and progenitor cells.
  • Severe bacterial infections increase myeloid cell turnover due to pathogen combat mechanisms.

Purpose of the Study:

  • To review the regulatory mechanisms governing myeloid cell production during infection.
  • To discuss established and emerging concepts in emergency hematopoiesis.

Main Methods:

  • This is a review article, synthesizing existing research.
  • It discusses regulatory pathways and cellular responses in hematopoiesis.

Main Results:

  • Steady-state hematopoiesis shifts to emergency hematopoiesis during severe bacterial infections.
  • This shift dramatically increases myeloid cell output to meet heightened demand.

Conclusions:

  • Understanding the regulation of emergency hematopoiesis is vital for combating infections.
  • Further research into these fundamental processes can inform therapeutic strategies.

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