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Infantile tremor syndrome: Role of Vitamin B12 revisited

Rajesh Gupta1, Jagdish Mandliya2, Pavan Sonker3

  • 1Department of Pediatrics, Chirayu Medical College, Bhopal, Madhya Pradesh, India.

Journal of Pediatric Neurosciences
|February 21, 2017
PubMed

Insights

This study investigated Vitamin B12's role in infantile tremor syndrome (ITS). Results were inconclusive, suggesting further research is needed to determine if B12 deficiency causes ITS.

Area of Science:

  • Pediatric Neurology
  • Nutritional Science

Background:

  • Infantile tremor syndrome (ITS) is a neurological disorder affecting infants.
  • The potential etiological role of Vitamin B12 deficiency in ITS requires further investigation.

Purpose of the Study:

  • To examine the association between Vitamin B12 levels and infantile tremor syndrome (ITS).

Main Methods:

  • Clinical assessment of 12 infants diagnosed with ITS.
  • Documentation of demographic, clinical, hematological, and biochemical data.
  • Serum Vitamin B12 levels were measured in all participants.

Main Results:

  • Two out of 12 ITS patients exhibited serum B12 levels below reference values.
  • Five patients had low-normal Vitamin B12 levels, while five had normal levels.
  • No definitive correlation was established between Vitamin B12 levels and ITS diagnosis.

Conclusions:

  • The role of Vitamin B12 deficiency as an etiological factor in infantile tremor syndrome (ITS) remains inconclusive.
  • Further studies are warranted to elucidate the complex causes of ITS.
Abstract

Keywords:
DevelopmentVitamin B12infantile tremor syndromenutrition

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