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The first report of onychomycosis caused by Cryptococcus friedmannii (Naganishia friedmannii) a basidiomycetous yeast

Masoome Ekhtiari1, Shirin Farahyar1, Mehraban Falahati1

  • 1Department of Medical Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Medical Mycology Case Reports
|February 21, 2017
PubMed

Insights

This study details a rare case of toenail fungus caused by Cryptococcus friedmannii. The yeast was successfully treated with common antifungal medications, offering insights into managing this infection.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Dermatology

Background:

  • Onychomycosis, a fungal nail infection, is frequently caused by yeasts.
  • While dermatophytes are common culprits, yeast infections of the nail are increasingly recognized.

Purpose of the Study:

  • To report a case of onychomycosis caused by *Cryptococcus friedmannii* (also known as *Naganishia friedmannii*).
  • To characterize the causative agent and determine its susceptibility to antifungal agents.

Main Methods:

  • Clinical case presentation.
  • Microscopic examination of nail scrapings.
  • Molecular identification using internal transcribed spacer (ITS) region sequencing.
  • Antifungal susceptibility testing.

Main Results:

  • *Cryptococcus friedmannii* was isolated from the great toenail of a 57-year-old male patient.
  • Microscopy revealed budding yeast cells with a thin capsule.
  • Sequence analysis confirmed the yeast's identity.
  • *C. friedmannii* demonstrated sensitivity to fluconazole, itraconazole, and amphotericin B.

Conclusions:

  • *Cryptococcus friedmannii* is a potential, albeit uncommon, cause of onychomycosis.
  • Standard antifungal therapies are effective against this yeast in nail infections.
  • This case highlights the importance of considering yeasts in the differential diagnosis of onychomycosis.
Keywords:
Antifungal susceptibilityBasidiomycetous yeastCryptococcus friedmanniiOnychomycosis

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