Related Experiment Video
Updated: Mar 7, 2026
Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
Published on: April 12, 2021
Profile of infections in renal transplant recipients from India
Arun Kumar1, Chaturbhuj Agarwal1, Ashok K Hooda1
1Department of Nephrology, Command Hospital, Lucknow, Uttar Pradesh, India.
Background:
Infectious disorders are a major cause of concern in renal transplant recipients (RTRs) leading to considerable morbidity and mortality. We studied the profile and outcomes of infectious disorders in a cohort of RTR.
Materials And Methods:
In this prospective, observational study, we evaluated all RTR who presented with the features of infection. We also included asymptomatic patients with microbiological evidence of infection. We excluded patients with acute rejection, drug toxicity, and malignancy. Descriptive statistics were used to analyze the results.
Results:
The study population (n = 45, 35 male and 10 female) had a mean age of 35.5 ± 10.4 years and follow-up after transplant was 2.1 ± 1.7 years. Urinary tract infection (UTI, n = 15) is the most common infection followed by tuberculosis (TB, n = 8), cytomegalovirus (n = 6), candidiasis (n = 7), and hepatitis (n = 11). Miscellaneous infections such as cryptosporidiosis and pneumocystis were seen in 10 patients. Simultaneous infections with two organisms were seen in 7 patients. Four patients succumbed to multiorgan dysfunction following sepsis, another 4 patients developed chronic graft dysfunction, while the remaining 35 RTR had a good graft function.
Conclusion:
Infectious complications are very common in the posttransplant period including UTI and TB. Further large scale studies are required to identify the potential risk factors leading to infections in RTR.
Insights
Infectious complications like urinary tract infections and tuberculosis are common in renal transplant recipients (RTRs). Understanding these infections is crucial for improving outcomes in RTRs.
Area of Science:
- Nephrology
- Transplant Surgery
- Infectious Diseases
Background:
- Infectious disorders pose significant risks for renal transplant recipients (RTRs), contributing to morbidity and mortality.
- This study investigates the spectrum and outcomes of infections in a cohort of RTRs.
Purpose of the Study:
- To analyze the profile and outcomes of infectious disorders in renal transplant recipients.
- To identify common infections and their impact on graft function and survival.
Main Methods:
- Prospective, observational study design.
- Inclusion of symptomatic and asymptomatic RTRs with microbiological evidence of infection.
- Exclusion of patients with acute rejection, drug toxicity, or malignancy.
Main Results:
- Urinary tract infection (UTI) was the most frequent (n=15), followed by hepatitis (n=11), tuberculosis (TB, n=8), and candidiasis (n=7).
- Cytomegalovirus (CMV), cryptosporidiosis, and pneumocystis infections were also observed.
- Four patients died from sepsis-induced multiorgan dysfunction, and four developed chronic graft dysfunction; 35 RTRs maintained good graft function.
Conclusions:
- Infectious complications, particularly UTI and TB, are highly prevalent post-renal transplantation.
- Further large-scale research is needed to pinpoint risk factors for infections in RTRs.
Related Concept Videos
01:28Kidney Transplant I: Introduction
01:26Kidney Transplant II: Surgical Procedure
01:16Kidney Transplant III: Nursing Management
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
01:27Acute Pyelonephritis I: Introduction