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Immunotoxin: A new tool for cancer therapy

Hossein Allahyari1, Sahar Heidari1, Mehdi Ghamgosha1

  • 11 Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
|February 21, 2017
PubMed

Cancer is one of the main reasons of death in the most countries and in Iran. Immunotherapy quickly became one of the best methods of cancer treatment, along with chemotherapy and radiation. "Immunotoxin Therapy" is a promising way of cancer therapy that is mentioned in this field. Immunotoxins are made from a toxin attaching to an antibody target proteins present on cancer cells. The first-generation immunotoxins were made of a full-length toxin attached to whole monoclonal antibodies. But, these immunotoxins could bind to normal cells. DAB389IL2 was the first immunotoxin approved by the Food and Drug Administration. Current trends and researches are ongoing on finding proteins that in combination with immunotoxins have minimal immunogenicity and the most potency for target cell killing.

Keywords:
Toxinsantibodycancer therapyimmunotoxins

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