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Related Experiment Video

Updated: Mar 7, 2026

Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid
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Vitamin A Acid in Acne.

S K Panja, S K Sen Gupta, S Bose

    Indian Journal of Dermatology, Venereology and Leprology
    |February 21, 2017
    PubMed
    Summary
    This summary is machine-generated.

    Topical vitamin A acid (retinoic acid) effectively treats acne, with lotions showing better results than creams. Local skin reactions indicate effective therapy and correlate with patient improvement.

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    Area of Science:

    • Dermatology
    • Dermatologic Therapeutics
    • Acne Vulgaris Treatment

    Background:

    • Topical treatments are crucial for managing acne vulgaris.
    • Understanding the efficacy and side effect profile of topical agents is essential.

    Purpose of the Study:

    • To evaluate the efficacy and tolerability of topical vitamin A acid (retinoic acid) in acne treatment.
    • To compare the effectiveness of lotion versus cream formulations.

    Main Methods:

    • A study involving 55 patients with acne vulgaris.
    • Application of topical vitamin A acid 0.05% in lotion and cream formulations.
    • Monitoring of local reactions, lesion clearance, and overall patient response.

    Main Results:

    • 83.6% of patients showed excellent response, particularly for papulo-pustular and comedone acne.
    • Lotion formulation was found to be more effective than cream.
    • Local skin reactions, occurring in most patients, were associated with therapeutic benefit and served as an indicator of efficacy.
    • Improvement was observed within 4-6 weeks, with lesion clearance by 8 weeks.
    • Mild demelanizing properties were noted, improving patient complexions.

    Conclusions:

    • Topical vitamin A acid is an effective treatment for various acne types, especially papulo-pustular and comedone acne.
    • The presence and intensity of local reactions can predict treatment success.
    • Lotion formulations may offer superior efficacy compared to creams.