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Ubiquitination and dynactin regulate TMEPAI lysosomal trafficking.

Shenheng Luo1, Lei Jing1, Tian Zhao1

  • 1School of Biotechnology, Tianjin University of Science and Technology, Key Lab of Industrial Fermentation Microbiology of the Ministry of Education, Tianjin, 300457, China.

Scientific Reports
|February 21, 2017
PubMed
Summary

The transmembrane prostate androgen-induced protein (TMEPAI) is transported to lysosomes via a clathrin and CI-M6PR pathway. Ubiquitination and specific protein interactions regulate this crucial TMEPAI trafficking mechanism in tumorigenesis.

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