Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Other Unique Bacteria01:18

Other Unique Bacteria

517
Magnetic bacteria exhibit a directed movement called magnetotaxis, driven by structures called magnetosomes. These magnetosomes consist of chains of magnetic particles made of either magnetite (Fe₃O₄) or greigite (Fe₃S₄) and are organized in a linear conformation by a protein scaffold within invaginations of the cell membrane. The bacteria align along the north–south magnetic field lines, much like a compass needle. They are typically microaerophilic or anaerobic...
517
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

799
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
799
Antimicrobial Proteins01:23

Antimicrobial Proteins

14.9K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
14.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Position paper. The role of epidemiology in urban health].

Epidemiologia e prevenzione·2026
Same author

Rapid improvement of nasal obstruction after treatment with a non-vasoconstrictive osmotic nasal spray: A prospective observational study.

American journal of otolaryngology·2026
Same author

Molecular detection of zoonotic pathogens in fleas collected from dogs and cats in Portugal.

Parasites & vectors·2026
Same author

Re-investigation of the HExxH enzyme DarF reveals a dehydrogenation-epoxidation reaction.

Organic & biomolecular chemistry·2026
Same author

A systematic review of surgical outcomes and postoperative complications based on free flap selection for reconstructing primary or recurrent locally advanced laryngeal-hypopharyngeal tumours.

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·2026
Same author

P450 Cyptide Synthase AscB Catalyzes Fused Cyclophane at the YxWxH Motif on the Precursor Peptides.

Organic letters·2026

Related Experiment Video

Updated: Mar 7, 2026

Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds
07:13

Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds

Published on: August 8, 2025

1.8K

Antibacterial Paramagnetic Quinones from Actinoallomurus.

Marianna Iorio1, João Cruz2, Matteo Simone1

  • 1Naicons Srl , Viale Ortles 22/4, 20139 Milano, Italy.

Journal of Natural Products
|February 21, 2017
PubMed
Summary

New potent antibacterial compounds, paramagnetoquinones A and B, were discovered in Actinoallomurus bacteria. These compounds exhibit strong activity against Gram-positive pathogens, including resistant strains, offering potential for novel antibiotic development.

More Related Videos

Growing Magnetotactic Bacteria of the Genus Magnetospirillum: Strains MSR-1, AMB-1 and MS-1
10:07

Growing Magnetotactic Bacteria of the Genus Magnetospirillum: Strains MSR-1, AMB-1 and MS-1

Published on: October 17, 2018

16.6K
Purification of the M. magneticum Strain AMB-1 Magnetosome Associated Protein MamAΔ41
11:07

Purification of the M. magneticum Strain AMB-1 Magnetosome Associated Protein MamAΔ41

Published on: March 25, 2010

14.0K

Related Experiment Videos

Last Updated: Mar 7, 2026

Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds
07:13

Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds

Published on: August 8, 2025

1.8K
Growing Magnetotactic Bacteria of the Genus Magnetospirillum: Strains MSR-1, AMB-1 and MS-1
10:07

Growing Magnetotactic Bacteria of the Genus Magnetospirillum: Strains MSR-1, AMB-1 and MS-1

Published on: October 17, 2018

16.6K
Purification of the M. magneticum Strain AMB-1 Magnetosome Associated Protein MamAΔ41
11:07

Purification of the M. magneticum Strain AMB-1 Magnetosome Associated Protein MamAΔ41

Published on: March 25, 2010

14.0K

Area of Science:

  • Natural Product Chemistry
  • Microbiology
  • Synthetic Biology

Background:

  • Actinomycetes are a prolific source of bioactive natural products.
  • Antibiotic resistance necessitates the discovery of novel antimicrobial agents.

Purpose of the Study:

  • To isolate and characterize new metabolites from Actinoallomurus species.
  • To evaluate the antibacterial potential of isolated compounds.
  • To elucidate the biosynthetic pathway of novel compounds.

Main Methods:

  • Isolation and purification of metabolites using chromatographic techniques.
  • Structure elucidation via NMR spectroscopy, mass spectrometry, and chemical derivatization.
  • Antibacterial activity testing using microdilution methods.
  • Bioinformatic analysis of the putative biosynthetic gene cluster.

Main Results:

  • Four paramagnetoquinones (1-4) were isolated from Actinoallomurus strains.
  • Compounds 1 and 2 demonstrated potent antibacterial activity (MIC < 0.015 μg/mL) against Gram-positive bacteria, including resistant strains.
  • Structure elucidation of NMR-silent compounds 1 and 2 was achieved through advanced analytical methods.
  • The paramagnetoquinones possess a unique carbon scaffold with dual quinone moieties and a fused lactone ring.
  • A likely biosynthetic gene cluster (pmq) was identified, revealing unique enzymes involved in polyketide synthesis.

Conclusions:

  • Paramagnetoquinones A and B represent a novel class of potent antibacterial agents.
  • The unique structural features and biosynthetic pathway offer insights into natural product drug discovery.
  • Further investigation into paramagnetoquinones could lead to the development of new antibiotics to combat resistant pathogens.