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[Allogeneic hematopoietic stem cell transplantation in Hungary]
Árpád Bátai1, Péter Reményi1, Marienn Réti1
1Egyesített Szent István és Szent László Kórház Budapest.
Orvosi Hetilap
|February 21, 2017
Summary
Allogeneic stem cell transplantation in Hungary has evolved, shifting indications and increasing recipient age due to reduced intensity conditioning. New regimens improve donor availability, expanding transplant accessibility.
Area of Science:
- Hematology
- Transplant Immunology
Background:
- The Szent László Hospital in Budapest has performed 2548 stem cell transplantations between 1993 and 2015.
- A detailed analysis focuses on 425 allogeneic stem cell transplantations conducted from 2007 to 2013.
Purpose of the Study:
- To summarize the evolution of allogeneic stem cell transplantation in Hungary.
- To compare the outcomes of a unique Hungarian allogeneic stem cell center.
Main Methods:
- Analysis of major steps in the evolution of allogeneic stem cell transplantation.
- Comparative analysis of results from the Hungarian allogeneic center.
Main Results:
- Transplantation indications shifted from chronic myeloid leukemia to myelodysplastic syndromes.
- Recipient age increased, influenced by reduced intensity conditioning regimens.
- Post-transplantation cyclophosphamide enabled HLA-incompatible transplants, improving donor availability.
Conclusions:
- Allogeneic stem cell transplantation is becoming less dependent on recipient age, comorbidities, and donor availability.
- Increased funding and new centers are needed for allogeneic stem cell transplantation in Hungary.