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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Matrix Metalloproteinases as Regulators of Periodontal Inflammation
Cavalla Franco1,2,3, Hernández-Ríos Patricia4, Sorsa Timo5,6
1Department of Conservative Dentistry, School of Dentistry, Universidad de Chile, Santiago 8380492, Chile. francocavalla@gmail.com.
Abstract:
Periodontitis are infectious diseases characterized by immune-mediated destruction of periodontal supporting tissues and tooth loss. Matrix metalloproteinases (MMPs) are key proteases involved in destructive periodontal diseases. The study and interest in MMP has been fuelled by emerging evidence demonstrating the broad spectrum of molecules that can be cleaved by them and the myriad of biological processes that they can potentially regulate. The huge complexity of MMP functions within the 'protease web' is crucial for many physiologic and pathologic processes, including immunity, inflammation, bone resorption, and wound healing. Evidence points out that MMPs assemble in activation cascades and besides their classical extracellular matrix substrates, they cleave several signalling molecules-such as cytokines, chemokines, and growth factors, among others-regulating their biological functions and/or bioavailability during periodontal diseases. In this review, we provide an overview of emerging evidence of MMPs as regulators of periodontal inflammation.
Insights
Matrix metalloproteinases (MMPs) are key proteases in periodontitis, regulating inflammation and tissue destruction. Emerging evidence highlights their complex role in immune responses and signaling molecule cleavage during periodontal disease.
Area of Science:
- Oral Biology
- Immunology
- Biochemistry
Background:
- Periodontitis is an infectious disease causing tissue destruction and tooth loss.
- Matrix metalloproteinases (MMPs) are crucial proteases implicated in periodontal diseases.
- MMPs regulate numerous physiological and pathological processes, including immunity and inflammation.
Purpose of the Study:
- To review emerging evidence on the role of MMPs in regulating periodontal inflammation.
- To explore the complexity of MMP functions within the 'protease web' in periodontal disease.
Main Methods:
- Literature review of emerging evidence on MMPs in periodontal disease.
- Analysis of MMPs' roles in immune-mediated tissue destruction.
- Examination of MMPs' cleavage of signaling molecules like cytokines and chemokines.
Main Results:
- MMPs are key proteases involved in the immune-mediated destruction of periodontal tissues.
- MMPs cleave extracellular matrix and signaling molecules, regulating their function and bioavailability.
- MMPs play a critical role in the inflammatory processes during periodontal diseases.
Conclusions:
- MMPs are significant regulators of periodontal inflammation.
- Understanding MMPs' complex functions is crucial for managing periodontal diseases.
- Further research into MMPs' roles may reveal new therapeutic targets.
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