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Related Experiment Videos

[Colonic neuroendocrinology].

R Willocx1

  • 1Service de Gastroentérologie, Clinique St-Jean, Bruxelles, Belgique.

Annales De Gastroenterologie Et D'Hepatologie
|June 1, 1987
PubMed
Summary
This summary is machine-generated.

The colon

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Area of Science:

  • Gastrointestinal Physiology
  • Neurogastroenterology
  • Autonomic Nervous System

Context:

  • The colon's function relies on intricate intrinsic and extrinsic neural networks.
  • Enteric plexi provide intrinsic innervation, forming neuro-enterocytic junctions and interconnections.
  • Extrinsic innervation involves the autonomic nervous system (parasympathetic and sympathetic), modulated by the central nervous system.

Purpose:

  • To detail the neurotransmitters and pathways involved in colonic innervation.
  • To elucidate the roles of various neurochemicals in mucosal and submucosal neurotransmission.
  • To describe diseases characterized by enteric plexus destruction.

Summary:

  • Intrinsic colonic innervation originates from enteric plexi, with axons forming neuro-enterocytic junctions.

Related Experiment Videos

  • Extrinsic innervation is governed by the autonomic nervous system, modulated by the CNS.
  • Neurotransmission involves acetylcholine (ACh) and vasoactive intestinal peptide (VIP) in the mucosa; serotonin and enkephalins in submucosal ganglia; ACh and VIP in parasympathetic pathways; and norepinephrine, dopamine, NPY, and histamine in sympathetic pathways. Prevertebral ganglia exhibit VIP and substance P activity. The roles of many CNS neuropeptides remain unidentified. Diseases involving enteric plexus destruction are also discussed.

    • Impact:

    • Provides a comprehensive overview of colonic neuroanatomy and neurochemistry.
    • Highlights the complexity of neural control in gastrointestinal function.
    • Establishes a foundation for understanding neurological disorders affecting the colon.