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Glomerular hyperfiltration is strongly correlated with age in Congolese children with sickle cell anaemia

Michel Ntetani Aloni1, René Makuala Ngiyulu1, Pépé Mfutu Ekulu1

  • 1Division of Hemato-oncology and Nephrology, Department of Pediatrics, University Hospital of Kinshasa, School of Medicine, University of Kinshasa, Kinshasa, the Democratic Republic of Congo.

Acta Paediatrica (Oslo, Norway : 1992)
|February 21, 2017
PubMed

Insights

Glomerular hyperfiltration is common in children with sickle cell anemia (SCA). Older age and lower body mass index are key risk factors for this condition, which can signal kidney damage.

Area of Science:

  • Nephrology
  • Pediatrics
  • Hematology

Background:

  • Glomerular hyperfiltration is an early indicator of sickle cell nephropathy.
  • It can progress to microalbuminuria and renal failure.
  • Identifying risk factors is crucial for prevention.

Purpose of the Study:

  • To identify risk factors associated with glomerular hyperfiltration in children with sickle cell anemia.
  • To understand the prevalence of hyperfiltration and microalbuminuria in this population.

Main Methods:

  • 150 children with sickle cell anemia (SCA) aged 2-18 years in Kinshasa were recruited.
  • Hyperfiltration defined as eGFR < 140 mL/min/1.73 m²; microalbuminuria as ACR 30-299 mg/g.
  • Logistic regression analysis identified independent determinants of hyperfiltration.

Main Results:

  • Glomerular hyperfiltration was present in 40% of children.
  • Children with hyperfiltration were older (10.2 vs. 7.9 years) and had lower BMI.
  • Increased age and decreased BMI were independent factors associated with hyperfiltration.

Conclusions:

  • Glomerular hyperfiltration is a common finding in children with SCA.
  • Age is a significant independent factor associated with hyperfiltration.
  • Further research is needed to explore the link between hyperfiltration, microalbuminuria, and renal outcomes in SCA.
Abstract

Keywords:
ChildrenGlomerular filtration rateMicroalbuminuriaRisk factorsSickle cell anaemia

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