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Factors Affecting the Risk of Infection01:26

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
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Factors associated with persistent colonisation with methicillin-resistant Staphylococcus aureus.

V C Cluzet1, J S Gerber2, I Nachamkin3

  • 1Division of Infectious Diseases,Department of Medicine,Perelman School of Medicine, University of Pennsylvania,Philadelphia,USA.

Epidemiology and Infection
|February 22, 2017
PubMed
Summary
This summary is machine-generated.

Persistent methicillin-resistant Staphylococcus aureus (MRSA) colonization is linked to white race, previous MRSA infections, and multiple colonization sites. Clindamycin treatment may reduce persistent MRSA colonization, warranting further investigation.

Keywords:
MRSA colonisationMRSA skin and soft tissue infectionsMethicillin-resistant Staphylococcus aureus (MRSA)persistent MRSA colonisation

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Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Microbiology

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant public health challenge, particularly concerning persistent colonization.
  • Understanding factors contributing to persistent MRSA colonization is crucial for developing effective control strategies.

Purpose of the Study:

  • To identify factors associated with persistent MRSA colonization in adults and children with skin and soft tissue infections.
  • To compare characteristics of individuals who cleared MRSA colonization versus those who remained persistently colonized.

Main Methods:

  • A prospective cohort study was conducted over three years at five academic medical centers.
  • Index cases with MRSA infections and their household members underwent serial self-sampling for MRSA colonization every two weeks for six months.
  • Persistent colonization was defined as no clearance (two consecutive negative samples) by study end.

Main Results:

  • Of 243 index cases, 19.8% exhibited persistent MRSA colonization.
  • Factors associated with persistent colonization included white race (OR 4.90), prior MRSA infection (OR 3.59), and colonization at multiple body sites (OR 32.7).
  • Individuals treated with clindamycin were less likely to have persistent colonization (OR 0.28).

Conclusions:

  • Colonization at multiple sites is a significant risk factor for persistent MRSA colonization.
  • Targeted decolonization efforts may be necessary for individuals with multi-site colonization.
  • The potential role of clindamycin in reducing persistent MRSA colonization requires further elucidation.