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Cardiac basal and activation metabolism.

D S Loiselle1

  • 1Department of Physiology, School of Medicine, University of Auckland, New Zealand.

Basic Research in Cardiology
|January 1, 1987
PubMed
Summary

Cardiac basal metabolism and activation metabolism are key energy expenditures in the heart. Mitochondrial proton pumping is a major, yet poorly understood, contributor to basal cardiac metabolism.

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Area of Science:

  • Cardiology
  • Biochemistry
  • Physiology

Background:

  • Cardiac metabolism encompasses basal and activation components, crucial for myocardial function.
  • Basal cardiac metabolism reflects energy expenditure in quiescent myocardium; activation metabolism fuels contraction.
  • Understanding these metabolic processes is vital for comprehending cardiac energetics.

Purpose of the Study:

  • To elucidate the components and contributing factors of cardiac basal and activation metabolism.
  • To quantify the relative contributions of basal and activation metabolism to overall cardiac energy expenditure.
  • To explore the role of mitochondrial proton pumping in cardiac basal metabolism.

Main Methods:

  • Review and analysis of existing literature on cardiac energy expenditure.
  • Calculations estimating the contribution of mitochondrial proton pumping to basal metabolism.
  • Comparison of energy expenditure in isolated muscle preparations and whole-heart studies.

Main Results:

  • Cardiac basal metabolism is species-dependent, influenced by pre-load, with minor contributions from cation pumps.
  • Mitochondrial proton pumping may account for a significant fraction of cardiac basal metabolism, though poorly understood.
  • Cardiac activation metabolism supports electrical excitation and excitation-contraction coupling, increasing with contractility and potentially pre-load.

Conclusions:

  • Both basal and activation metabolism contribute substantially, each representing one-quarter to one-third of total cardiac energy expenditure.
  • Mitochondrial function is a critical, albeit not fully elucidated, determinant of cardiac basal metabolic rate.
  • Further research is needed to fully understand the mechanisms underlying cardiac basal metabolism.

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