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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

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Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
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Cardiomyopathy II: Dilated Cardiomyopathy01:30

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Articles linked to this work by shared authors, journal, and citation graph.

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Unexpected twist: large marginal branch occlusion of the left circumflex artery unveiled by immediate and pivotal cardiac magnetic resonance imaging in a 19-year-old with suspected myocarditis-a case report.

European heart journal. Case reports·2026
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Cardiac implantable electronic device upgrades and downgrades: a Clinical Consensus Statement of the European Heart Rhythm Association (EHRA) of the ESC, the Asia Pacific Heart Rhythm Association (APHRS), Canadian Heart Rhythm Society (CHRS), Heart Rhythm Society (HRS), and the Latin American Heart Rhythm Society (LAHRS).

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2025
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[Resynchronization of left bundle branch block by His bundle pacing : A case series].

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[Update device therapy].

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[Comment on the European Society of Cardiology (ESC) Clinical Consensus Statement on the indication for conduction system pacing].

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European Society of Cardiology (ESC) clinical consensus statement on indications for conduction system pacing, with special contribution of the European Heart Rhythm Association of the ESC and endorsed by the Asia Pacific Heart Rhythm Society, the Canadian Heart Rhythm Society, the Heart Rhythm Society, and the Latin American Heart Rhythm Society.

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Related Experiment Video

Updated: Mar 7, 2026

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
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[ICD in elderly patients].

Carsten W Israel1

  • 1Klinik für Innere Medizin - Kardiologie, Diabetologie & Nephrologie, Evangelisches Krankenhaus Bielefeld, Burgsteig 13, 33617, Bielefeld, Deutschland. Carsten.Israel@evkb.de.

Herzschrittmachertherapie & Elektrophysiologie
|February 22, 2017
PubMed
Summary
This summary is machine-generated.

Implantable cardioverter-defibrillator (ICD) therapy improves prognosis, not symptoms. Decisions for elderly patients require individual assessment of life expectancy, quality of life, and patient preferences.

Keywords:
ComorbidityElderly patientsEnd of lifeImplantable cardioverter defibrillatorPrognosis

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Area of Science:

  • Cardiology
  • Medical Ethics

Background:

  • Implantable cardioverter-defibrillators (ICDs) offer prognostic benefits but not symptomatic relief.
  • Patient selection for ICD implantation requires careful consideration of life expectancy and quality of life.

Purpose of the Study:

  • To evaluate the prognostic benefit and safety of ICD therapy in elderly patients.
  • To provide guidance on individualizing ICD implantation decisions in older adults.

Main Methods:

  • Review of existing data on ICD use in elderly populations.
  • Analysis of factors influencing prognostic benefit, including age, comorbidity, and patient preferences.

Main Results:

  • Elderly patients experience similar rates of appropriate ICD therapy compared to younger patients.
  • Complication rates for ICD implantation and lead longevity are not higher in the elderly.
  • Prognostic benefit in primary prevention is less clear in the elderly due to higher competing mortality.

Conclusions:

  • ICD indication in elderly patients should be individualized, considering life expectancy, comorbidity, biological age, and patient preferences.
  • Age alone should not be a barrier to ICD implantation; complications are not more frequent.
  • Deactivation of shock therapy should be discussed with elderly patients nearing end-of-life.