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Wave-CAIPI for highly accelerated MP-RAGE imaging.

Daniel Polak^1,2, Kawin Setsompop^1,3,4, Stephen F Cauley^1,3

¹Department of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA.

Magnetic Resonance in Medicine

|February 22, 2017

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Wave-controlled aliasing in parallel imaging (wave-CAIPI) enables highly accelerated T1-weighted MP-RAGE MRI. This technique significantly reduces scan times while maintaining excellent image quality and low g-factors.

Area of Science:

Magnetic Resonance Imaging
Medical Physics
Radiology

Background:

T1-weighted magnetization-prepared rapid gradient echo (MP-RAGE) is a crucial MRI sequence.
Achieving high acceleration in MP-RAGE often compromises image quality due to g-factor noise amplification.

Purpose of the Study:

To introduce a novel, highly accelerated T1-weighted MP-RAGE acquisition using wave-controlled aliasing in parallel imaging (wave-CAIPI).
To demonstrate that wave-CAIPI encoding can maintain high image quality at accelerated scan rates.

Main Methods:

Implemented wave-CAIPI encoding with sinusoidal waveforms to spread aliasing in all three directions, improving the g-factor.
Integrated a rapid (2 s) coil sensitivity acquisition and data-driven trajectory calibration for an online acquisition-reconstruction pipeline.

Keywords:

CAIPIRINHA ESPIRiT MP-RAGE fast imaging wave-CAIPI

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Main Results:

Achieved a 9-fold accelerated MP-RAGE acquisition in 71 seconds at 3T with excellent g-factors (gmax=1.27, gavg=1.06).
Demonstrated a 12-fold acceleration in 57 seconds at 7T (gmax=1.15, gavg=1.04).
Outperformed state-of-the-art 2D-CAIPIRINHA in acceleration and g-factor performance.

Conclusions:

Wave encoding effectively overcomes g-factor noise amplification limitations in parallel imaging.
This approach enables an order of magnitude acceleration for MP-RAGE acquisitions, significantly improving efficiency.