Related Experiment Video
Updated: Mar 7, 2026
Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
Published on: May 23, 2021
Fungal Contamination of Methylprednisolone Causing Recurrent Lumbosacral Intradural Abscess
Abstract:
Fungal meningitis transmitted through injections of methylprednisolone contaminated with Exserohilum rostratum affected 753 persons and caused 61 deaths in the United States in 2012. We report a case of infection recurrence after 24-months with the unique manifestation of an intradural fungal abscess. Fungal disease should remain on the differential diagnosis list for previously exposed patients.
Insights
Fungal meningitis outbreaks, like the 2012 methylprednisolone contamination, can recur. This case highlights a rare intradural fungal abscess, emphasizing the need for vigilance in previously exposed patients.
Area of Science:
- * Infectious Diseases
- * Mycology
- * Neurology
Background:
- * The 2012 outbreak of fungal meningitis in the United States was linked to methylprednisolone injections contaminated with Exserohilum rostratum.
- * This outbreak affected 753 individuals and resulted in 61 fatalities, underscoring the severe public health impact of contaminated medical products.
Observation:
- * A case of recurrent fungal meningitis is presented, occurring 24 months after the initial infection.
- * The recurrence uniquely manifested as an intradural fungal abscess, a rare complication.
Findings:
- * Recurrence of fungal meningitis, even after a significant disease-free interval, is possible.
- * Intradural fungal abscess represents a unique and severe manifestation of infection recurrence.
Implications:
- * Fungal meningitis and its potential for late recurrence must remain a key consideration in the differential diagnosis for patients with a history of exposure.
- * This case emphasizes the importance of long-term monitoring for patients treated for fungal infections, especially those linked to contaminated pharmaceutical products.
