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Related Concept Videos

Surface Membrane Barriers01:18

Surface Membrane Barriers

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The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
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Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Mucosal Barrier of the Stomach01:25

Mucosal Barrier of the Stomach

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The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
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Cells of the Epidermis01:24

Cells of the Epidermis

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The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
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Tissue Membranes01:27

Tissue Membranes

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A tissue membrane is a thin layer of cells that covers the outside of the body, the organs, internal passageways that lead to the exterior of the body, and the lining of the moveable joint cavities. There are two basic types of tissue membranes— connective tissue and epithelial membranes.
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The connective tissue membrane is formed solely from connective tissue. These membranes encapsulate organs, such as the kidneys, and line our movable joints. A synovial...
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Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Related Experiment Video

Updated: Mar 7, 2026

Mucin Agarose Gel Electrophoresis: Western Blotting for High-molecular-weight Glycoproteins
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Mucin Agarose Gel Electrophoresis: Western Blotting for High-molecular-weight Glycoproteins

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Study on Mucin in Normal-Appearing Leg Skin.

Angel Fernandez-Flores1

  • 1Consultant Histopathologist, Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain.

The American Journal of Dermatopathology
|February 22, 2017
PubMed
Summary

Dermal mucin deposits in the legs are not a normal part of aging. This study found no mucin in aged individuals without skin disease, suggesting such deposits indicate an abnormal condition.

Area of Science:

  • Dermatology
  • Histopathology
  • Aging Research

Background:

  • Dermal mucin deposits in the legs are often linked to venous insufficiency.
  • Stasis dermatitis, common in aged individuals, may lead to the assumption of inherent dermal mucin with aging.

Purpose of the Study:

  • To investigate the presence of dermal mucin in the reticular dermis of aged individuals without dermatologic disease.
  • To determine if dermal mucin deposits are an inherent aspect of aging in the legs.

Main Methods:

  • Histopathological analysis of cutaneous leg samples from 15 aged autopsy cases.
  • Staining with hematoxylin and eosin, iron, and Alcian blue to assess dermal components.
  • Grading of iron deposits and evaluation for signs of stasis like neovascularization.

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Profiling of Permethylated Mucin O-glycans Using Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry

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CUBIC Protocol Visualizes Protein Expression at Single Cell Resolution in Whole Mount Skin Preparations
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CUBIC Protocol Visualizes Protein Expression at Single Cell Resolution in Whole Mount Skin Preparations

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Last Updated: Mar 7, 2026

Mucin Agarose Gel Electrophoresis: Western Blotting for High-molecular-weight Glycoproteins
09:24

Mucin Agarose Gel Electrophoresis: Western Blotting for High-molecular-weight Glycoproteins

Published on: June 14, 2016

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Profiling of Permethylated Mucin O-glycans Using Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry
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Profiling of Permethylated Mucin O-glycans Using Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry

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CUBIC Protocol Visualizes Protein Expression at Single Cell Resolution in Whole Mount Skin Preparations
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CUBIC Protocol Visualizes Protein Expression at Single Cell Resolution in Whole Mount Skin Preparations

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Main Results:

  • All investigated skin samples showed a score of 0 for dermal mucin deposits in the reticular dermis.
  • Iron deposits and signs of stasis, such as neovascularization, were observed in some cases.
  • No correlation was found between aging and the presence of dermal mucin.

Conclusions:

  • Dermal mucin deposits in the legs are not a natural consequence of aging.
  • The presence of mucin in the reticular dermis or periadnexal dermis should be considered abnormal.
  • These findings challenge the previous assumption linking aging with dermal mucin accumulation in the legs.