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Updated: Mar 7, 2026

Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1-/- Mice

Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1-/- Mice

Published on: October 17, 2018

ZIKA-RELATED MACULOPATHY.

Chee Wai Wong^1,2, Si Rui Ng^1,2, Chui Ming Gemmy Cheung^1,2,3

¹Singapore National Eye Centre, Medical Retina Department, Singapore, Singapore.

Retinal Cases & Brief Reports

|February 22, 2017

Summary

This summary is machine-generated.

This case report details a patient with Zika virus infection who developed unilateral maculopathy, presenting as blurred vision and macular dysfunction. The condition resolved with conservative management, highlighting a potential ocular manifestation of Zika virus.

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Modelling Zika Virus Infection of the Developing Human Brain In Vitro Using Stem Cell Derived Cerebral Organoids

Published on: September 19, 2017

Area of Science:

Ophthalmology
Infectious Diseases
Virology

Background:

Zika virus infection is a growing public health concern.
Ocular manifestations of Zika virus are increasingly reported.
Understanding the spectrum of ophthalmic complications is crucial for patient management.

Observation:

A 22-year-old male presented with acute vision blurring 10 days post-Zika virus symptom onset.
Clinical examination revealed unilateral maculopathy in the right eye.
The left eye remained unaffected.

Findings:

Ophthalmoscopy, fluorescein angiography, indocyanine green angiography, and OCT showed unilateral maculopathy.
Multifocal electroretinography confirmed localized macular dysfunction in the affected eye.
Zika virus infection was confirmed via RT-PCR.

Implications:

This case suggests unilateral maculopathy as a potential ophthalmic complication of Zika virus infection.
Early recognition and conservative management may lead to favorable visual outcomes.
Further research is needed to elucidate the pathogenesis and long-term effects of Zika-associated maculopathy.