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Updated: Mar 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Nocardia keratitis: A case report.

S Matuska¹, P Rama, A Cavallero

¹Department of Ophthalmology and Visual Sciences, University Hospital San Raffaele, Milano - Italy.

European Journal of Ophthalmology

|February 22, 2017

Summary

This summary is machine-generated.

Nocardia keratitis can be resistant to topical amikacin, potentially causing severe reactions. Combination antibiotics and cautious corticosteroid use are vital for managing this infection.

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Area of Science:

Ophthalmology
Medical Microbiology

Background:

Nocardia keratitis is a serious ocular infection.
Treatment challenges include antibiotic resistance and patient tolerance.

Purpose of the Study:

To report a case of Nocardia keratitis with amikacin resistance and adverse reactions.
To evaluate alternative treatment strategies and the role of corticosteroids.

Main Methods:

Diagnosis of Nocardia asteroides via smear, culture, and biochemical analysis.
Treatment involved escalating topical amikacin, followed by a combination antibiotic therapy (chloramphenicol, tetracycline, colistin, ofloxacin).

Main Results:

Initial 2% amikacin was ineffective; 5% amikacin caused a toxic-allergic reaction.
Combination therapy led to rapid improvement, but infection recurred after corticosteroid use.
Prolonged combination antibiotic treatment (3 months) was successful.

Conclusions:

Topical amikacin may be ineffective for Nocardia keratitis.
Fortified amikacin can cause severe reactions; combination therapy is a viable alternative.
Topical corticosteroids pose a risk of relapse and should be used cautiously.