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Morphological study of tooth development in podoplanin-deficient mice
Kenyo Takara1, Naoki Maruo2, Kyoko Oka1
1Department of Oral Growth & Development, Fukuoka Dental College, Fukuoka, Japan.
Plos One
|February 22, 2017
Summary
Podoplanin is crucial for respiratory function but not essential for tooth and bone development. Studies on knockout mice show normal tooth and alveolar bone growth, indicating podoplanin
Area of Science:
- Cell Biology
- Developmental Biology
- Glycoprotein Research
Background:
- Podoplanin is a highly O-glycosylated glycoprotein found in various somatic cells.
- It is known to be involved in cell signaling, cytoskeleton dynamics, and alveolar cell differentiation.
- Complete absence of podoplanin is lethal at birth due to respiratory failure, limiting research on adult somatic cell functions.
Purpose of the Study:
- To investigate the role of podoplanin in tooth germ development.
- To examine dentin formation in mice with podoplanin deficiency in neural crest-derived cells.
Main Methods:
- Utilized podoplanin-knockout mice and conditional knockout mice (Wnt1-Cre;PdpnΔ/Δ).
- Analyzed tooth germ development and dentin formation in genetically modified mice.
Main Results:
- Mice lacking podoplanin in neural crest-derived cells (Wnt1-Cre;PdpnΔ/Δ) exhibited normal tooth and alveolar bone morphology and growth.
- Podoplanin deficiency did not lead to abnormalities in tooth or bone development in these models.
Conclusions:
- Podoplanin is not critical for the development of teeth and alveolar bone.
- Its essential role appears to be primarily in respiratory function and potentially other developmental processes not assessed in this study.
