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Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
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Related Experiment Video

Updated: Mar 7, 2026

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
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Correction: Relaxation Response Induces Temporal Transcriptome Changes in Energy Metabolism, Insulin Secretion and

Manoj K Bhasin, Jeffery A Dusek, Bei-Hung Chang

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    Summary

    This study corrects a previously published article DOI. The correction ensures accurate citation and referencing for scientific literature. Researchers should use the updated DOI for all future citations.

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    Area of Science:

    • Bibliometrics
    • Scientific Publishing

    Context:

    • Correction of a published article DOI.
    • Ensuring accurate referencing in scientific literature.

    Purpose:

    • To provide the correct article DOI for citation.
    • To maintain the integrity of scientific records.

    Summary:

    • This entry serves as a correction notice for a specific article DOI.
    • The updated DOI is provided to ensure proper attribution and tracking of the research.

    Impact:

    • Facilitates accurate citation and avoids misattribution.
    • Supports reliable scientific communication and literature searching.
    • Maintains the integrity of the scientific record.