Related Experiment Video

Updated: Mar 7, 2026

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
05:57

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

1.3K

Relationship between hyperuricemia and risk of coronary heart disease in a middle-aged and elderly Chinese population

Ye Yang1, Jian Tian1, Chao Zeng1

  • 11 Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.

The Journal of International Medical Research
|February 23, 2017
PubMed

Insights

Hyperuricemia, or high uric acid levels, is linked to increased coronary heart disease (CHD) risk in middle-aged and elderly Chinese individuals. This finding suggests hyperuricemia may be an independent risk factor for CHD.

Area of Science:

  • Cardiology
  • Metabolic Disorders
  • Epidemiology

Background:

  • Coronary heart disease (CHD) poses a significant health burden.
  • Hyperuricemia is a metabolic condition characterized by elevated uric acid levels.
  • The association between hyperuricemia and CHD risk requires further investigation, particularly in diverse populations.

Purpose of the Study:

  • To examine the relationship between hyperuricemia and the 10-year risk of coronary heart disease (CHD).
  • To assess this association in a middle-aged and elderly Chinese population using the Framingham risk score (FRS).

Main Methods:

  • A cross-sectional study involving 6347 patients undergoing routine check-ups.
  • Hyperuricemia defined by specific uric acid thresholds for males and females.
  • Multivariable logistic regression analysis was employed to evaluate associations after adjusting for confounding factors.

Main Results:

  • The prevalence of hyperuricemia was 18.1% in the study population.
  • Patients with hyperuricemia showed an increased 10-year CHD risk compared to those without.
  • This increased risk was observed in the total population (OR 1.28), males (OR 1.25), and notably in females (OR 3.76).

Conclusions:

  • Hyperuricemia is positively associated with an increased 10-year risk of coronary heart disease.
  • The findings suggest that hyperuricemia may serve as an independent risk factor for CHD.
  • This highlights the potential importance of monitoring uric acid levels in middle-aged and elderly individuals for cardiovascular risk assessment.

Keywords:
Framingham risk scoreHyperuricemiacoronary heart disease risk

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.4K
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
786
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
294
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
689
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
497
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.3K