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Updated: Mar 7, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
Antimalarial solid self-emulsifying system for oral use: in vitro investigation.
Sameer Bhandari1, Vikas Rana1, Ashok K Tiwary1
1Pharmaceutics Division, Department of Pharmaceutical Sciences & Drug Research, Punjabi University, Patiala, Punjab 147 002, India.
Developing solid self-microemulsifying drug-delivery systems (SMEDDS) enhanced artemether and lumefantrine bioavailability. Solid SMEDDS improved drug release and absorption compared to traditional tablets.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Low aqueous solubility of artemether and lumefantrine limits bioavailability.
- Self-microemulsifying drug-delivery systems (SMEDDS) can enhance solubility and absorption.
Purpose of the Study:
- To develop solid SMEDDS for artemether and lumefantrine.
- To evaluate the stability and drug release of the developed solid SMEDDS.
Main Methods:
- Optimized liquid SMEDDS containing artemether and lumefantrine were adsorbed onto Neusilin US2®.
- Spray drying was employed to convert liquid SMEDDS into solid SMEDDS.
- Drug assay, dissolution rate, and globule size were analyzed.
Main Results:
- Solid SMEDDS achieved approximately 90% drug release within 15 minutes.
- Drug assay and dissolution rates remained stable after 3-month storage under accelerated conditions (40°C/75% RH).
- Reconstituted solid SMEDDS formed microemulsions with a globule size of 67.74 nm.
Conclusions:
- Solid SMEDDS formulation effectively enhances artemether and lumefantrine bioavailability.
- The developed solid SMEDDS demonstrate good stability and superior in vitro drug release compared to marketed tablets.
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