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Related Experiment Videos

Methotrexate encephalopathy. A neuropathologic study.

H M Liu, H S Maurer, S Vongsvivut

    Human Pathology
    |November 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Necrotizing encephalopathy in acute lymphoblastic leukemia patients resulted from methotrexate therapy and irradiation. This neuropathologic study reveals white matter damage, suggesting a vascular endothelial injury mechanism.

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    Area of Science:

    • Neuropathology
    • Neuro-oncology
    • Toxicology

    Background:

    • Intrathecal methotrexate and craniospinal irradiation are standard treatments for acute lymphoblastic leukemia (ALL).
    • Severe adverse neurological events, including necrotizing encephalopathy, can occur following these therapies.
    • Understanding the neuropathologic basis of these complications is crucial for patient management.