Recent advances in biomedical applications of fluorescent gold nanoclusters

Fluorescent gold nanoclusters (AuNCs) are emerging as novel fluorescent materials and have attracted more and more attention in the field of biolabeling, biosensing, bioimaging and targeted cancer treatment because of their unusual physicochemical properties, such as long fluorescence lifetime, ultrasmall size, large Stokes shift, strong photoluminescence, as well as excellent biocompatibility and photostability. Recently, significant efforts have been committed to the preparation, functionalization and biomedical application studies of fluorescent AuNCs. In this review, we have summarized the strategies for preparation and surface functionalization of fluorescent AuNCs in the past several years, and highlighted recent advances in the biomedical applications of the relevant fluorescent AuNCs. Based on these observations, we also give a discussion on the current problems and future developments of the fluorescent AuNCs for biomedical applications.