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Effect of sodium depletion on pressor responsiveness in ACTH-induced hypertension in man
J M Connell1, B M Fisher, G Davidson
1MRC Blood Pressure Unit, Western Infirmary, Glasgow, Scotland.
Clinical and Experimental Pharmacology & Physiology
|March 1, 1987
Abstract:
1. Pressor responsiveness to angiotensin II (AII) and phenylephrine (PHE) was measured before and after 5 days of ACTH (1 mg i.m. daily) in six normal men maintained on low sodium diet (15 mmol daily). 2. ACTH caused a significant increase in systolic blood pressure of 9 mmHg. 3. There was no change in pressor responsiveness to AII with ACTH. 4. ACTH increased pressor responsiveness to PHE for both systolic and diastolic blood pressure, with a fall in the threshold for response from 0.9 to 0.6 micrograms/kg per min. 5. Increased pressor sensitivity to catecholamines during ACTH administration in man is not sodium-dependent.