Related Experiment Video
Updated: Mar 7, 2026
10:21
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
940
Interleukin 32, inflammation and cancer
Jin Tae Hong1, Dong Ju Son1, Chong Kil Lee1
1College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31 Osongsaengmyeong 1-ro, Osong-eup, Heungduk-gu, Cheongju, Chungbuk 361-951, Republic of Korea.
Pharmacology & Therapeutics
|February 23, 2017
Summary
Interleukin-32 (IL-32) is a cytokine implicated in inflammation and cancer. This review explores IL-32
Area of Science:
- Immunology
- Molecular Biology
- Oncology
Background:
- Interleukin-32 (IL-32) is a novel cytokine with diverse roles in cellular processes.
- IL-32 exhibits multiple alternatively spliced isoforms and is primarily expressed in immune cells.
- Its involvement in inflammatory diseases and cancer development is complex and context-dependent.
Purpose of the Study:
- To review recent findings on the roles of IL-32 isoforms in disease development.
- To discuss therapeutic strategies targeting IL-32 for inflammatory diseases and cancers.
- To highlight the potential of IL-32 as a therapeutic target.
Main Methods:
- Literature review of existing studies on IL-32.
- Analysis of IL-32's involvement in various inflammatory conditions and malignancies.
- Exploration of potential therapeutic approaches targeting IL-32 and its isoforms.
Main Results:
- IL-32 expression is altered in numerous inflammatory diseases and cancers, with contradictory reports on its upregulation or downregulation.
- IL-32 has been linked to both the promotion and inhibition of tumor development across various cancer types.
- Specific IL-32 isoforms may play distinct roles in disease pathogenesis.
Conclusions:
- IL-32 is a significant factor in the pathogenesis of inflammatory diseases and cancers.
- Targeting IL-32 presents a promising therapeutic avenue for treating these conditions.
- Further research into IL-32 isoforms is crucial for developing effective targeted therapies.
Related Concept Videos
01:24T Cell Types and Functions
3.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.0K
01:27Tumor Immunotherapy
2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K
02:17The Tumor Microenvironment
8.0K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.0K
01:19Psychoneuroimmunology: Diabetes and Cancer
562
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
562
01:20The JAK-STAT Signaling Pathway
13.5K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
13.5K
01:28Inflammatory Response
17.7K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
17.7K